Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 75, Issue 3, Pages 422-427Publisher
WILEY
DOI: 10.1189/jlb.0403194
Keywords
cytokine; tyrosine kinase; Toll-like receptor; STAT; NF-kappa B; inflammatory bowel disease; rheumatoid antithesis; endotoxin
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Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. These cytokines exert their biological functions through Janus tyrosine kinases and signal transducer and activator of transcription factors. The cytokine-inducible Sre homology 2 protein (CIS) and suppressors of cytokine signaling (SOCS) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that regulate the inflammatory systems. In this short review, we focused on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in Toll-like receptor signal regulation and inflammatory diseases.
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