Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 484, Issue 2, Pages 117-121Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2008.10.034
Keywords
Tyrosine; Nitration; Nitrotyrosine; Peroxynitrite; Nitric oxide; Peroxidase; Oxidative stress
Categories
Funding
- National Institutes of Health [HL54926]
- NIA [AG13966, ES013508]
- NIEHS Center of Excellence in Environmental Toxicology
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Tyrosine nitration is a covalent post-translational protein modification derived from the reaction of proteins with nitrating agents. Tyrosine nitration has been used as a marker of oxidant burden in human diseases. However, it remains unclear whether protein nitration is responsible for alterations in protein function that imparts an increased risk for disease development or unfavorable outcomes. Emerging data implicate tyrosine nitration as a mediator of immune responses Suggesting a novel biological function for this protein modification. (C) 2008 Elsevier Inc. All rights reserved.
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