Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 490, Issue 2, Pages 77-84Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2009.08.015
Keywords
Endothelium; Free radicals; Oxidative stress; Oxidative damage; Smooth muscle cells; Serum
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The exact origin of reactive species and oxidative damage detected in blood is largely unknown. Blood interacts with all organs and tissues and, consequently, with many possible sources of reactive species. In addition, a multitude of oxidizable substrates are already in blood. A muscle-centric approach is frequently adopted to explain reactive species generation, which obscures the possibility that Sources of reactive species and oxidative damage other than skeletal muscle may be also at work during exercise. Plasma and blood cells can autonomously produce significant amounts of reactive species at rest and during exercise. The major reactive species generators located in blood during exercise may be erythrocytes (mainly due to their quantity) and leukocytes (mainly due to their drastic activation during exercise). Therefore, it is plausible to assume that oxidative stress/damage measured frequently in blood after exercise or any other experimental intervention derives, at least in part, from the blood. (C) 2009 Elsevier Inc. All rights reserved.
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