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CANADIAN MEDICAL ASSOCIATION JOURNAL
Volume 170, Issue 5, Pages 821-824Publisher
CMA-CANADIAN MEDICAL ASSOC
DOI: 10.1503/cmaj.1030478
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ASYMPTOMATIC ELEVATION OF THE INTERNATIONAL normalized ratio (INR) is a common problem associated with hemorrhage. Evidence from randomized controlled trials supports the use of low-dose oral vitamin K therapy as a treatment that promptly reduces the INR. Vitamin K given orally is more effective than subcutaneous vitamin K injection, and as effective as intravenous administration when INR values are compared 24 hours after administration. A 1.0-mg vitamin K dose is likely most appropriate for, patients with INR values between 4.5 and 10. The fear of overcorrection of the INR has limited the widespread use of vitamin K; however, our review suggests that this occurs infrequently when small doses are administered orally.
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