Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 149, Issue 2, Pages 113-122Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0166-4328(03)00221-3
Keywords
schizophrenia; positive symptoms; negative symptoms; latent inhibition; attention
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Latent inhibition (LI), retarded conditioning to a stimulus that has been previously repeatedly presented without reinforcement, was examined in young schizophrenics and normal controls using a within-subject visual search task. Healthy controls exhibited the usual LI effect. LI was potentiated in schizophrenics who simultaneously exhibited high levels of negative symptoms and low levels of positive symptoms. Schizophrenic groups with other combinations of positive and negative symptoms did not differ from controls. The pattern of data suggests that past inconsistencies in the LI-schizophrenia literature may be the result of opposing processes that are associated with positive and negative symptoms. (C) 2003 Elsevier B.V. All rights reserved.
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