Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 56, Issue 4, Pages 491-509Publisher
ELSEVIER
DOI: 10.1016/j.addr.2003.10.017
Keywords
colon cancer; targeted drug delivery; prodrug; polymers; liposomes; review
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Targeting of drugs to specific sites of action provides several advantages over non-targeted drugs. These include the prevention of side effects of drugs on healthy tissues and enhancement of drug uptake by targeted cells. This review will cover traditional approaches of colon drug targeting as well as the use of lectins and neoglycoconjugates for the targeted delivery. Direct and reverse targeting strategies, potential molecular targets and targeting moieties for colon drug delivery, targeted drug delivery systems (DDS) for colon delivery, anticancer DDS targeted to colon cancer are examined. Directions of future development are discussed. (C) 2003 Elsevier B.V. All rights reserved.
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