Journal
NEUROSCIENCE LETTERS
Volume 357, Issue 2, Pages 131-134Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2003.12.046
Keywords
schizophrenia; luminance contrast; gabor patches; vision; lateral connections
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The aim of this study was to investigate lateral connectivity in early visual cortex of schizophrenia patients. Contrast thresholds were measured for centrally presented Gabor patches which were surrounded by two collinear or orthogonal flankers. The healthy subjects (n = 15) showed lower contrast thresholds for central Gabor patches when collinear flankers were presented. This effect was significantly reduced in unmedicated highly functioning schizophrenia patients (n = 20) who performed normally on the continuous performance test. The performance of the patients did not correlate with the positive and negative symptoms. The facilitation effect of collinear flankers is believed to reflect lateral interactions between feature-specific units in early visual cortex (V I). Our results therefore suggest abnormal lateral interactions in early visual cortex of schizophrenia patients. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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