4.8 Article

Preparation and synthetic applications of 2-halotryptamines: Synthesis of elacomine and isoelacomine

Journal

ORGANIC LETTERS
Volume 6, Issue 5, Pages 711-713

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol030138x

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Funding

  1. NIEHS NIH HHS [P30 ES 00210] Funding Source: Medline

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The preparation of 2-halotryptamines from tryptamine is described. New stereoselective intramolecular iminium ion spirocyclization methodology for the construction of spiro[pyrrolidine-3,3'-oxindoles] is outlined in synthetic studies of elacomine (1) and isoelacomine (2).

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