Journal
NEUROSCIENCE LETTERS
Volume 357, Issue 2, Pages 111-114Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/j.neulet.2003.11.073
Keywords
mitochondrial DNA; neurodegeneration; aging
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Mitochondrial dysfunction caused by mitochondrial DNA (mtDNA) aberrations has been implicated in the neuronal death in neurodegenerative disorders. Significant neuronal damage can occur if the percentage of mtDNA mutations may reach a critical threshold. mtDNA mutations also accumulate during normal aging. Here we quantified the 5 kB common mtDNA deletion (CD) using real-time PCR in various brain regions from neurodegenerative disorders and controls. We confirmed previous results that the CD levels increase with age, reaching highest levels in the basal ganglia. High CD levels were also found in affected regions in frontotemporal dementia, Parkinson's disease, and dementia with Lewy bodies, but not in Alzheimer's disease. This suggests that mtDNA damage may occur in a region-specific distribution in neurodegenerative disorders. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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