Journal
CANCER LETTERS
Volume 205, Issue 1, Pages 55-60Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/j.canlet.2003.11.014
Keywords
p73 two linked polymorphism; p53 Arg72Pro polymorphism; cervical cancer; polymerase chain reaction with confronting two-pair primers
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To examine the possible association between cervical cancer and p73 G4C14-to-A4T14 in exon 2 and p53 Arg72Pro polymorphisms, an incident case-control study was conducted in Japanese. The cases were 112 cervical cancer patients. Controls were 320 healthy women and 122 non-cancer female outpatients. Risk estimation for each genotype by an unconditional logistic model demonstrated a possible association between the p73 A4T14 variant and the risk of cervical cancer in our Japanese population (OR = 1.57; 95%CI, 0.99-2.48, P = 0.053). There was no significant difference in the p53 Arg72Pro genotype frequency between the controls and cases. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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