Journal
FEMS MICROBIOLOGY LETTERS
Volume 232, Issue 1, Pages 75-81Publisher
OXFORD UNIV PRESS
DOI: 10.1016/S0378-1097(04)00017-5
Keywords
Mycobacterium marinum; signature-tagged mutagenesis; mycobacterium; virulence; pathogenesis; goldfish model
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Mycobacterium marinum, a causative agent of fish tuberculosis, is one of the most closely related Mycobacterium species (outside the M. tuberculosis complex) to M. tuberculosis, the etiologic agent of human tuberculosis. Signature-tagged mutagenesis was used to identify genes of M. marinum required for in vivo survival in a goldfish model of mycobacterial pathogenesis. Screening the first 1008 M. marinum mutants led to the identification of 40 putative virulence mutants. DNA sequence analysis of these 40 mutants identified transposon insertions in 35 unique loci. Twenty-eight out of 33 (85%) loci encoding putative virulence genes have homologous genes in M. tuberculosis. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
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