Journal
VACCINE
Volume 22, Issue 9-10, Pages 1314-1319Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2003.08.039
Keywords
pertussis; sero-epidemiology; UK
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The incidence of pertussis infection can be estimated in the population by defining a single high titre of anti pertussis toxin (PT) immunoglobulin G (IgG) antibody predictive of recent infection. Sera samples collected in 1986, 1996 or annually between 1987 and 1998 were tested for anti-PT IgG antibody. In 1996, the age-adjusted prevalence of pertussis infection was 1.2% and was higher in children than in adults. Amongst samples collected annually, older age and female sex, but none of the temporal variables, were associated with a serologically defined pertussis infection. There is an important incidence of infection in the population, which is greater amongst children than adults, but there is only limited evidence of a correlation with epidemic cycles. (C) 2003 Elsevier Ltd. All rights reserved.
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