Journal
FEBS LETTERS
Volume 561, Issue 1-3, Pages 69-74Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(04)00118-8
Keywords
nuclear receptor; nuclear factor-kappa B; interleukin-6; cyclooxygenase-2; vascular smooth muscle cell
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Rev-erbalpha and retinoic acid receptor-related orphan receptor-alpha (RORalpha) are orphan nuclear receptors but their effects on transcription are opposed. Here, we show that Rev-erbalpha was expressed predominantly in vascular smooth muscle cells (VSMCs) rather than endothelial cells. Overexpression of Rev-erbalpha upregulated the expression of interleukin-6 and cyclooxygenase-2, and increased transactivation by NF-kappaB and translocation of p65 to the nucleus in A7r5 VSMCs. Furthermore, the expression of Rev-erbalpha was upregulated by RORalpha1 but that upregulation was attenuated by Rev-erbalpha itself in A7r5 VSMCs. These results suggest a regulatory link between Reverbalpha and the NF-kappaB pathway. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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