Journal
SCIENCE
Volume 303, Issue 5664, Pages 1678-1681Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1091031
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- NEI NIH HHS [R37 EY002874-24S1, R37 EY002874] Funding Source: Medline
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The mammalian visual cortex is organized into columns. Here, we examine cortical influences upon developing visual afferents in the cat by altering intrinsic gamma-aminobutyric acid (GABA)-mediated inhibition with benzodiazepines. Local enhancement by agonist (diazepam) infusion did not perturb visual responsiveness, but did widen column spacing. An inverse agonist (DMCM) produced the opposite effect. Thus, intracortical inhibitory circuits shape the geometry of incoming thalamic arbors, suggesting that cortical columnar architecture depends on neuronal activity.
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