Journal
BLOOD
Volume 103, Issue 6, Pages 2214-2220Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2003-08-2978
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Funding
- NCI NIH HHS [CA98027, R01 CA70275] Funding Source: Medline
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Although the alpha2beta1 integrin is widely expressed and has been extensively studied, it has not been previously implicated in mast cell biology. We observed that alpha2 integrin subunit-deficient mice exhibited markedly diminished neutrophil and interleukin-6 responses during Listeria monocytogenes- and zymosan-induced peritonitis. Since exudative neutrophils of wild-type mice expressed little alpha2beta1 integrin, it seemed unlikely that this integrin mediated neutrophil migration directly. Here, we demonstrate constitutive alpha2beta1 integrin expression on peritoneal mast cells. Although alpha2-null mice contain normal numbers of peritoneal mast cells, these alpha2-null cells do not support in vivo mast cell-dependent inflammatory responses. We conclude that alpha2beta1 integrin provides a costimulatory function required for mast cell activation and cytokine production in response to infection. (C) 2004 by The American Society of Hematology.
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