Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 98, Issue 2-3, Pages 328-336Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2003.09.037
Keywords
valves; paraffin; PCR; MicroTAS
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A new thermally actuated valving concept using paraffin as single-use valving material was developed. The paraffin undergoes a phase transition in response to changes in temperature. A variety of single-use paraffin-based microvalves, including close-open, open-close-open, T, and toggle designs, were demonstrated. Fluidic experiments showed that these microvalves had zero leakage and a maximum hold-up pressure of 40 psi in a closed position. A DNA polymerase chain reaction microdevice containing paraffin-based microvalves to enclose the sample solution in the reaction chamber during the thermal cycling was demonstrated. The paraffin-based microvalving technique has advantages over many existing active microvalve approaches, including a simple design, ease of fabrication, low cost, and ease of integration into complex microfluidic systems. Moreover, this technique is particularly attractive for single-use and disposable microfluidic devices. (C) 2003 Elsevier B.V. All rights reserved.
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