Journal
ONCOGENE
Volume 23, Issue 11, Pages 2028-2036Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1207389
Keywords
beta-TrCP; F-box; ubiquitin ligase; NF-kappa B; beta-catenin
Funding
- NCI NIH HHS [CA 92900] Funding Source: Medline
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Beta-transducin repeats-containing proteins (beta-TrCP) serve as the substrate recognition subunits for the SCFbeta-TrCP E3 ubiquitin ligases. These ligases ubiquitinate specifically phosphorylated substrates and play a pivotal role in the regulation of cell division and various signal transduction pathways, which, in turn, are essential for many aspects of tumorigenesis. We review the functions of the SCFbeta-TrCP ligases in the light of their relevance to cell growth, survival and transformation. Mechanisms underlying beta-TrCP regulation and their aberration in human and animal cancer as well as prospective of targeting beta-TrCP as a means of anticancer therapy are also discussed.
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