Journal
TETRAHEDRON LETTERS
Volume 45, Issue 12, Pages 2575-2577Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2004.01.154
Keywords
solvent free; multicomponent; microwave; Biginelli reaction; spiro-fused heterocyclic rings; Meldrum's acid; barbituric acid
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Spiro-fused heterocycles were synthesized in good to high yields by a pseudo four-component reaction of an aldehyde, urea and a cyclic beta-diester or a beta-diamide such as Meldrum's acid or barbituric acid derivatives using microwave irradiation under solvent-free conditions. (C) 2004 Elsevier Ltd. All rights reserved.
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