Journal
BRAIN RESEARCH BULLETIN
Volume 63, Issue 2, Pages 127-131Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.brainresbull.2004.01.007
Keywords
newborn; cerebral circulation; K+ channels; excitatory amino acids; signal transduction
Categories
Ask authors/readers for more resources
This study was designed to characterize the role of ATP sensitive (K-ATP) and calcium sensitive (K-ca) K+ channel activation in N-methyl-D-aspartate (NMDA)-induced pial artery dilation in newborn pigs equipped with a closed cranial window. NMDA (10(-8), 10(-6)M) elicited pial artery dilation that was blunted by the K-ATP channel antagonist glibenclamide (10(-6) M) and attenuated by the K-ca channel antagonist iberiotoxin (10(-7) M) (8 +/- 1% and 14 +/- 1% versus 2 +/- 1% and 4 +/- 1% versus 5 +/- 1% and 9 +/- 2% for NMDA in the absence and presence of glibenclamide or iberiotoxin. respectively). Combined administration of glibenclamide and iberiotoxin essentially eliminated the response. Similar results were observed for glutamate. These data show that NMDA elicits cerebrovasodilation through activation of K-ATP and K-ca channels in newborn pigs. C (C) 2004 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available