Journal
BIOLOGICAL PSYCHIATRY
Volume 55, Issue 6, Pages 656-658Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2003.09.018
Keywords
septum pellucidum; stress disorders; posttraumatic; magnetic resonance imaging; twins; monozygotic
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Funding
- NIMH NIH HHS [K05 MH070047, K05 MH070047-03, K02-MH01110, R01 MH054636, R01 MH054636-06, R01-MH54636] Funding Source: Medline
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Background Abnormally large cavum septum pellucidum has been reported in posttraumatic stress disorder; however, the origin of this association is uncertain. Methods: We utilized magnetic resonance imaging to measure cavum septum pellucidum in pairs of identical twins discordant for combat exposure in Vietnam. Results: Presence of abnormal cavum septum pellucidum was significantly correlated between exposed and unexposed twins, indicating that it is partially determined by heredity and/or shared environment. There was a greater proportion of cavum septum pellucidum in combat-exposed twins with posttraumatic stress disorder and their noncombat-exposed co-twins. Conclusions. The presence of abnormally large cavum septum pellucidum is a familial vulnerability factor for posttraumatic stress disorder.
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