Journal
BIOLOGICAL PSYCHIATRY
Volume 55, Issue 6, Pages 648-651Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2003.10.017
Keywords
bipolar disorder; voxel-based morphometry; frontal lobe; gray matter; brain; magnetic resonance imaging
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Funding
- PHS HHS [MGH58681] Funding Source: Medline
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Background: This study was conducted to explore differences in gray and white matter density between bipolar and healthy comparison groups using voxel-based morphometry (VBM). Methods. Brain magnetic resonance imaging was performed for 39 subjects with bipolar I disorder and 43 comparison subjects. Images were registered into a proportional stereotaxic space and segmented into gray matter, white mater, and cerebrospinal fluid. Statistical parametric mapping was used to calculate differences in gray and white matter density between groups. Results: Bipolar subjects bad decreased gray matter density in left anterior cingulate gyrus (Brodmann's area [BA] 32, 7.3% decrease), an adjacent left medial frontal gyrus (BA 10, 6.9% decrease), right inferior frontal gyrus (BA 4 7, 9.2% decrease), and right precentral gyrus (BA 44, 6.2% decrease), relative to comparison subjects. Conclusions. The observation of a gray matter density decrease in the left anterior cingulate, which processes emotions, in bipolar subjects is consistent with prior reports that used region-of-interest analytic methods. Decreased gray matter density in the light inferior frontal gyrus, which processes nonverbal and intrinsic functions, supports nondominant hemisphere dysfunction as a component of bipolar disorder.
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