Journal
MOLECULAR BRAIN RESEARCH
Volume 122, Issue 1, Pages 93-98Publisher
ELSEVIER
DOI: 10.1016/j.molbrainres.2003.12.001
Keywords
protease-activated receptor; thrombin; trimethyltin; neurodegeneration; astrocyte
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Thrombin, its main inhibitor (protease nexin-1) and its related receptors (protease-activated receptors, PAR-1,-2, -3, -4) were studied in rat hippocampus following administration of trimethyltin (TMT), a neurotoxin inducing neuronal degeneration and reactive gliosis. Reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry revealed that while expression of prothrombin and protease nexin-1 did not change significantly in TMT-treated hippocampi, PARs (in particular PAR-I and to a lesser extent PAR-2 and PAR-3) were upregulated in reactive astrocytes, suggesting their involvement in neurodegeneration and in the consequent response of the nervous tissue. (C) 2003 Elsevier B.V. All rights reserved.
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