Journal
JOURNAL OF NEUROSCIENCE
Volume 24, Issue 11, Pages 2742-2749Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3960-03.2004
Keywords
neurotrophin; receptor; high-affinity binding; p75; NGF; Trk
Categories
Funding
- NCI NIH HHS [CA56490] Funding Source: Medline
- NINDS NIH HHS [R01 NS021072, NS21072, R56 NS021072] Funding Source: Medline
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Nerve growth factor (NGF) functions as a ligand for two receptors, the TrkA tyrosine kinase receptor and the p75 neurotrophin receptor (p75(NTR)). The Ig-like domains of Trk receptors and the cysteine-rich repeats of p75(NTR) are involved in binding to the neurotrophins. Recently, a closely related gene to p75(NTR) called neurotrophin receptor homolog-2 (NRH2) was identified; however, the function of NRH2 and its relevance to neurotrophin signaling are unclear. NRH2 contains a similar transmembrane and intracellular domain as p75(NTR) but lacks the characteristic cysteine-rich repeats in the extracellular domain. Here we show that NRH2 is expressed in several neuronal populations that also express p75(NTR) and Trk receptors. NRH2 does not bind to NGF; however, coimmunoprecipitation experiments demonstrate that NRH2 is capable of interacting with TrkA receptors. Coexpression of NRH2 with TrkA receptors resulted in the formation of high-affinity binding sites for NGF. These results indicate that a transmembrane protein related to p75(NTR) is capable of modulating Trk receptor binding properties.
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