Journal
ORGANIC LETTERS
Volume 6, Issue 6, Pages 1049-1052Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol049852k
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- NCI NIH HHS [CA24487] Funding Source: Medline
- NCRR NIH HHS [P20 RR-16455-02] Funding Source: Medline
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Two novel hybrid polyketide-terpenoid metabolites were isolated from a Penicillium sp. growing in the Berkeley Pit Lake of Butte, Montana. Their structures were deduced by spectroscopic analysis and confirmed by single-crystal X-ray analysis on berkeleydione (1). Both compounds inhibited matrix metalloproteinase-3 and caspase-1, and berkeleydione showed activity toward non-small-cell lung cancer in NCI's human cell line antitumor screen.
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