Journal
ORGANIC LETTERS
Volume 6, Issue 6, Pages 1013-1016Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol049921v
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[GRAPHICS] A novel and practical synthesis of 3-substituted 3H-pyrimidin-4-ones is described. The key step involves the cyclization of enamide esters, derived from readily available beta-keto esters, with trimethylaluminum and various primary amines.
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