Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 47, Issue 7, Pages 1602-1604Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm034244g
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The melanocortin 4 receptor (MC4R) plays an important role in body weight regulation and energy homeostasis. Administration of peptidic MC4R antagonists (usually by intracerebro ventricular injection) has been shown in the literature to increase body weight and/or food intake in sever rodent models. We report here the identification of a novel nonpeptidic MC4R antagonist and its effects on tumor-induced weight loss in mice following peripheral administration.
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