Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 802, Issue 1, Pages 155-166Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jchromb.2003.10.053
Keywords
reviews; heterocyclic aromatic amine-DNA adducts; DNA
Funding
- NCI NIH HHS [1R01CA69390] Funding Source: Medline
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The detection and quantification of heterocyclic aromatic amine (HAA)-DNA adducts, critical biomarkers in interspecies extrapolation of toxicity data for human risk assessment, remains a challenging analytical problem. The two main analytical methods currently in use to screen for HAA-DNA adducts are the P-32-postlabeling assay and mass spectrometry, using either accelerated mass spectrometry (AMS) or liquid chromatography and electrospray ionization mass spectrometry (LC-ESI-MS). In this review, the principal methods to synthesize and characterize DNA adducts, and the methods applied to measure HAA-DNA adduct in vitro and vivo are discussed. (C) 2003 Elsevier B.V. All rights reserved.
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