Journal
FEBS LETTERS
Volume 562, Issue 1-3, Pages 211-215Publisher
WILEY
DOI: 10.1016/S0014-5793(04)00246-7
Keywords
prostaglandin; neurotrophin; astrocyte; neuroprotection; nervous system
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We found that prostaglandin (PG) D-2 and PGE(2), which are major PGs in the brain of mammals, powerfully induced the secretion of nerve growth factor (NGF) from cultured mouse astrocytes; PGE(2) or PGD(2) induced an approximately 12- or 19-fold increase in NGF secretion after a 24-h incubation, respectively. Moreover, it was found that the sequential metabolites of PGD(2), PGJ(2), Delta(12)-PGJ(2), and 15-deoxy-Delta(12,14)- PGJ(2), induced the NGF secretion to the culture medium strikingly (60-98-fold of the control after a 24-h incubation). NGF secretion induced by the J(2) series of PGs was accompanied by the increased expression of NGF mRNA. These PGs also stimulated the secretion/synthesis of brain-derived neurotrophic factor (BDNF). Our findings suggest that PGs play a neuroprotective role by inducing NGF and BDNF production in the central nervous system. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. Ail rights reserved.
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