Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 279, Issue 13, Pages 12001-12004Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R300038200
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Funding
- NHLBI NIH HHS [R01 HL 075092] Funding Source: Medline
- NIGMS NIH HHS [R01 GM 47214] Funding Source: Medline
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Mechanical forces are crucial to the regulation of cell and tissue morphology and function. At the cellular level, forces influence cytoskeletal organization, gene expression, proliferation, and survival. Integrin-mediated adhesions are intrinsically mechanosensitive and a large body of data implicates integrins in sensing mechanical forces. We review the relationship between integrins and mechanical forces, the role of integrins in cellular responses to stretch and fluid flow, and propose that some of these events are mechanistically related.
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