Journal
JOURNAL OF AFFECTIVE DISORDERS
Volume 174, Issue -, Pages 397-399Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jad.2014.12.009
Keywords
Anterior cingulate cortex; Cognitive behavioral therapy; Depression; Magnetic resonance imaging; Voxel-based morphometry
Categories
Funding
- Japan Society for the Promotion of Science [23791326]
- SENSHIN Medical Research Foundation
- Ministry of Education, Culture, Sports, Science and Technology of japan [22220003, 24243061, 23118004, 23120009]
- Health and Labour Science Research Grant for Comprehensive Research on Disability Health and Welfare from Ministry of Health, Labour, and Welfare [H25-seishin-jitsuyouka-ippan-001]
- Grants-in-Aid for Scientific Research [23791326, 15H01690, 22220003] Funding Source: KAKEN
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Background: Cognitive behavioral therapy (CBT) is widely used to treat major depressive disorder (MDD). Although improved response prediction could facilitate the development of individualized treatment plans, few studies have investigated whether underlying brain structure is related to CBT response in MDD. Methods: Ten MDD patients who received individual CBT were studied in this study. We investigated the relationship between the regional gray matter (GM) volume and subsequent responses to CBT using voxel-based morphometry. Results: The degree of improvement in depressive symptoms was positively correlated with GM volume in the caudal portion of the anterior cingulate cortex. Limitations: The sample size was small, and the effects of medication on the results could not be excluded. Conclusions: Our results, although preliminary, suggest that the anterior cingulate cortex is a key structure whose volume can be used to predict responses to CBT and is thus a potential prognostic marker in MDD. (C) 2014 Elsevier B.V. All rights reserved,
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