Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 101, Issue 13, Pages 4643-4648Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0400922101
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Funding
- NHLBI NIH HHS [HL70694, P01 HL070694] Funding Source: Medline
- NINDS NIH HHS [R01 NS010861, F31 NS045440, F31 NS010861, NS45440, R37 NS044916, R01 NS044916, R01 NS041078, NS41078, NS10861, NS44916] Funding Source: Medline
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Myelin is a dynamic, functionally active membrane necessary for rapid action potential conduction, axon survival, and cytoarchitecture. The number of debilitating neurological disorders that occur when myelin is disrupted emphasizes its importance. Using high-resolution 2D gel electrophoresis, mass spectrometry, and immunoblotting, we have developed an extensive proteomic map of proteins present in myelin, identifying 98 proteins corresponding to at least 130 of the approximate to200 spots on the map. This proteomic map has been applied to analyses of the localization and function of selected proteins, providing a powerful tool to investigate the diverse functions of myelin.
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