Journal
JOURNAL OF NEUROSCIENCE
Volume 24, Issue 13, Pages 3295-3303Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4098-03.2004
Keywords
delay activity; neuronal clock; firing rate adaptation; Hebbian synaptic plasticity; learning cellular timers; Weber law in interval timing
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The brain has the ability to represent the passage of time between two behaviorally relevant events. Recordings from different areas in the cortex of monkeys suggest the existence of neurons representing time by increasing ( climbing) activity, which is triggered by a first event and peaks at the expected time of a second event, e. g., a visual stimulus or a reward. When the typical interval between the two events is changed, the slope of the climbing activity adapts to the new timing. We present a model in which the climbing activity results from slow firing rate adaptation in inhibitory neurons. Hebbian synaptic modifications allow for learning the new time interval by changing the degree of firing rate adaptation. This event-based representation of time is consistent with Weber's law in interval timing, according to which the error in estimating a time interval is proportional to the interval length.
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