Journal
JOURNAL OF NEUROSCIENCE
Volume 24, Issue 13, Pages 3289-3294Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.5338-03.2004
Keywords
cortex; epilepsy; network; synchrony; transport; N-methyl-D-aspartate
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Glutamate transporters are operative at an early developmental stage well before synapse formation, but their functional significance has not been determined. We now report that blockade of glutamate transporters in the immature neocortex generates recurrent NMDA receptor-mediated currents associated with synchronous oscillations of [Ca2+](i) in the entire neuronal population. Intracerebroventricular injections of the blocker to pups generate seizures that are prevented by coinjections of NMDA receptor blockers. Therefore, the early expression of glutamate transporters plays a central role to prevent the activation by local glutamate concentrations of NMDA receptors and the generation of seizures that may alter the construction of cortical networks. A dysfunction of glutamate transporters may be a central event in early infancy epilepsy syndromes.
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