Journal
CANCER LETTERS
Volume 206, Issue 1, Pages 107-113Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2003.10.024
Keywords
Wif-1; Apc(Min/+) mice; intestinal adenomas; cDNA-representational difference analysis
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Using cDNA-Representational Difference Analysis it was found that expression of Opg, Ctse, Krt2-4, Fut-2, 24p3 and Wif-1 genes was elevated in intestinal adenomas as compared to normal epithelial cells of Apc(Min/+) mutant mice. Expression of Wif-1, which encodes Wnt inhibitory factor-1 was also detected in a number of tumor cell lines of epithelial cell origin including two human colon adenocarcinoma cell lines. The possible role of Wif-1 over-expression in the etiology of colorectal cancer is discussed. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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