Journal
JOURNAL OF BACTERIOLOGY
Volume 186, Issue 8, Pages 2402-2412Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.186.8.2402-2412.2004
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Funding
- NIAID NIH HHS [AI30492, R37 AI030492, R01 AI030492] Funding Source: Medline
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An essential component of all type III secretion systems is a highly conserved ATPase that shares significant amino acid sequence similarity to the beta subunit of the F0F1 ATPases and is thought to provide the energy for the secretion process. We have performed a genetic and functional analysis of InvC, the ATPase associated with the Salmonella enterica type III secretion system encoded within its pathogenicity island 1. Through a mutagenesis analysis, we have identified amino acid residues that are essential for specific activities of InvC, such as nucleotide hydrolysis and membrane binding. This has allowed us to define discrete domains of InvC that are specifically associated with different essential activities of this protein.
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