Journal
PHYSIOLOGY & BEHAVIOR
Volume 81, Issue 2, Pages 223-241Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.physbeh.2004.02.014
Keywords
leptin; obesity; feeding; hypothalamus; neuropeptide
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Funding
- NIDDK NIH HHS [P30DK19525] Funding Source: Medline
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The discovery of leptin was a major breakthrough in our understanding of the role of adipose tissue as a storage and secretory organ. Leptin was initially thought to act mainly to prevent obesity; however, studies have demonstrated profound effects of leptin in the response to fasting, regulation of neuroendocrine and immune systems, hematopoiesis, bone and brain development. This review will focus on the signaling pathways which mediate these diverse effects of leptin in the brain and other physiologic systems. (C) 2004 Elsevier Inc. All rights reserved.
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