Journal
TRENDS IN GENETICS
Volume 20, Issue 4, Pages 196-205Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2004.02.006
Keywords
-
Categories
Funding
- NCI NIH HHS [N01-CO-12400] Funding Source: Medline
Ask authors/readers for more resources
Sperm typing offers an efficient means of studying the quantitative and qualitative aspects of meiotic recombination, that are virtually unapproachable by pedigree analysis. Since the initial development of the technique >10 years ago, several salient findings based on empirically derived recombination data have been described. The precise rates and distributions of recombination have been reported for specific regions of the genome, serving as the prototype for high-resolution genome-wide recombination patterns. Identification and characterization of molecular genetic events, such as unequal crossing over, gene conversion and crossover asymmetry, are under close inspection for the first time as a result of this technology. The influence of these phenomena on the evolution of the genome is of primary interest from a scientific and medical perspective. In this article, we review the novel discoveries in mammalian meiotic recombination that have been revealed through sperm typing.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available