Journal
SEMINARS IN CANCER BIOLOGY
Volume 14, Issue 2, Pages 105-114Publisher
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2003.09.015
Keywords
Ras; oncogene; signaling; invasion; metastasis
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The processes by which cancer cells leave the tumor and enter adjacent tissue is known as invasion, whereas metastasis refers to secondary tumor colonization of tissue at a distance from the primary lesion. These two events are the most lethal of cancer phenomena and the signaling mechanisms that govern them are complex. The Ras signaling pathways are well represented in their involvement in tumor initiation, but considerably less is known about their contribution to invasion and metastasis. In this review, we discuss the current evidence for mutant Ras proteins as significant players in these aspects of cancer progression. (C) 2003 Elsevier Ltd. All rights reserved.
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