Journal
TRENDS IN MOLECULAR MEDICINE
Volume 10, Issue 4, Pages 179-186Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2004.02.007
Keywords
-
Funding
- NHLBI NIH HHS [R37HL41002, R01 HL053756, P01HL56949, R01HL53756, R37 HL041002, P01 HL056949] Funding Source: Medline
Ask authors/readers for more resources
The adhesion receptor P-selectin has long been known to support leukocyte rolling and emigration at sites of inflammation. Recently, P-selectin was also revealed to be a key molecule in hemostasis and thrombosis, mediating platelet rolling, generating procoagulant microparticles containing active tissue factor and enhancing fibrin deposition. Elevated levels of plasma P-selectin are indicative of thrombotic disorders and predictive of future cardiovascular events. Because the interaction between P-selectin and its receptor P-selectin glycoprotein ligand-1 (PSGL-1) represents an important mechanism by which P-selectin induces the formation of procoagulant microparticles and recruits the microparticles to thrombi, anti-thrombotic strategies are currently aimed at inhibiting this interaction. Recent developments also suggest that the procoagulant potential of P-selectin could be used to treat coagulation disorders such as hemophilia A.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available