Journal
BEHAVIORAL NEUROSCIENCE
Volume 118, Issue 2, Pages 383-388Publisher
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.118.2.383
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Funding
- NIA NIH HHS [AG07648] Funding Source: Medline
- NIDA NIH HHS [DA 16951] Funding Source: Medline
- NINDS NIH HHS [NS32914] Funding Source: Medline
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Rats received bilateral injections of lidocaine or artificial cerebrospinal fluid (aCSF) into the dorsolateral striatum 6 min prior to training in either a plus- or T-shaped maze under cue-poor or cue-available conditions. Lidocaine injections significantly impaired acquisition in the cue-poor environments, but not in the cue-available environments. In addition, aCSF control rats trained in a plus-maze in a cue-poor environment reached criterion much more rapidly than did rats trained in a cue-available environment. These findings suggest that cue availability can permit acquisition of response learning in a manner that is not dependent on activity of the striatum. However, in a cue-poor environment, alternate strategies may be less readily available, revealing more efficient striatal involvement in response learning.
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