Journal
PHYSIOLOGY & BEHAVIOR
Volume 81, Issue 2, Pages 243-248Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.physbeh.2004.02.006
Keywords
diet-induced obesity; hyperinsulinemia; hyperlipidemia; catecholamines
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The development of the metabolic syndrome in an increasing percentage of the populations of Western societies, particularly in the United States, requires valid models for establishing basic biochemical changes and performing preclinical studies on potential drug targets. The C57BL/6J mouse has become an important model for understanidng the interplay between genetic background and environmental challenges such as high-fat/high-calorie diets that predispose to the development of the metabolic syndrome. This review highlights metabolic and signal transduction features that are altered during the course of disease progression, many of which mirror the human situation. (C) 2004 Published by Elsevier Inc.
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