Interleukin receptor-associated kinase (IRAK-4) deficiency associated with bacterial infections and failure to sustain antibody responses

We previously described a girl with recurrent episodes of pneumococcal pneumonia with septicemia and other infections,(1) ;found to have interleukin-1 receptor-associated kinase 4 deficiency (IRAK-4) deficieney.(2) In this report, we show that our patient is unable to sustain antibody responses either to polysaccharide or protein antigens or to a neoantigen-bacteriophage.