Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 5, Issue 4, Pages 261-270Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1357
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- Fondazione Telethon Funding Source: Custom
- Telethon [E.1254] Funding Source: Medline
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Junctional structures maintain the integrity of the endothelium. Recent studies have shown that, as well as promoting cell - cell adhesion, junctions might transfer intracellular signals that regulate contact-induced inhibition of cell growth, apoptosis, gene expression and new vessel formation. Moreover, modifications of the molecular organization and intracellular signalling of junctional proteins might have complex effects on vascular homeostasis.
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