4.2 Article

Coronamycins, peptide antibiotics produced by a verticillate Streptomyces sp (MSU-2110) endophytic on Monstera sp.

Journal

MICROBIOLOGY-SGM
Volume 150, Issue -, Pages 785-793

Publisher

MICROBIOLOGY SOC
DOI: 10.1099/mic.0.26645-0

Keywords

-

Categories

Ask authors/readers for more resources

Coronamycin is a complex of novel peptide antibiotics with activity against pythiaceous fungi and the human fungal pathogen Cryptococcus neoformans. It is also active against the malarial parasite, Plasmodium falciparum, with an IC50 of 9(.)0 ng ml(-1). Coronamycin is produced by a verticillate Streptomyces sp. isolated as an endophyte from an epiphytic vine, Monstera sp., found in the Manu region of the upper Amazon of Peru. Bioassay-guided fractionation of the fermentation broths of this endophyte on silica gel and H PLC chromatography yielded two principal, inseparable, peptides with masses of 1217(.)9 and 1203(.)8 Da. Three other minor, but related components, are also present in the preparation. Amino acid analysis of coronamycin revealed residues of component 1, component 2, methionine, tyrosine and leucine at a ratio of 2 : 2 :1 :1 : 3. Other compounds with antifungal activities are also produced by this endophytic streptomycete.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.2
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available