Journal
PLANTA MEDICA
Volume 70, Issue 4, Pages 334-341Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2004-818945
Keywords
quercetin; verapamil; mineralocorticoid hypertension; antioxidant; vascular reactivity; endothelial dysfunction
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This study analysed and compared the effects of chronic oral treatment with quercetin or verapamil on systolic blood pressure and vascular function in deoxycorticosterone acetate (DOCA)salt hypertensive rats. Quercetin and verapamil inhibited the development of DOCA-salt-induced hypertension in a similar manner. DOCA-salt-hypertensive rats showed potassium depletion and oxidative stress, prevented only by concomitant quercetin administration. Quercetin and verapamil treatments reduced the endothelium-independent hyper-reactivity to KCI observed in the aorta of DOCA-salt-hypertensive rats, but only quercetin increased the contractile responses to angiotensin 11, improved endothelial dysfunction and restored basal aortic Cu/Zn SOD expression, altered in DOCA-salt-treated rats. In conclusion, quercetin and verapamil show similar antihypertensive effects in mineralocorticoid hypertension, but quercetin was superior to verapamil in improving endothelial-dependent aortic dilatation, suggesting a better vascular protection in this volume expansion hypertension model.
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