Journal
LEUKEMIA RESEARCH
Volume 28, Issue 4, Pages 367-372Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2003.09.002
Keywords
multidrug resistance; AML; BCRP; MDR1; real-time PCR; quantitative PCR
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Expression of two MDR genes, BCRP and MDR1, was evaluated by real-time PCR technique in 51 AML patients. Fifty-six percent expressed the BCRP gene, with the 48.2% showing intermediate levels. Eighty-eight percent expressed the MDR1, with 23.8% of cases at high expression. A significant correlation between BCRP and MDR1 values was found by regression analysis. Either levels of BCRP or MDR1 did not correlate with clinical characteristics of patients at diagnosis. (C) 2003 Elsevier Ltd. All rights reserved.
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