Journal
JOURNAL OF NEUROBIOLOGY
Volume 59, Issue 1, Pages 24-33Publisher
WILEY
DOI: 10.1002/neu.10337
Keywords
neuropilin; plexin; semaphorin; axon guidance; ganglion formation
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The semaphorin receptors neuropilin and plexin were initially identified as antigens for monoclonal antibodies MAb-A5 and MAb-B2, which bind to specific neuropiles and plexiform layers within the Xenopus tadpole nervous systems, several years before the discovery of the first semaphorin. This article provides an overview of how neuropilin and plexin were discovered. In addition, it describes the functions of neuropilin in the signaling of chemorepulsive activities of class 3 semaphorins and roles of neuropilin-mediated semaphorin activities in the directional guidance of the peripheral nervous system (PNS) and integration of the peripheral ganglia. (C) 2004 Wiley Periodicals, Inc.
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