Journal
NEUROSCIENTIST
Volume 10, Issue 2, Pages 93-98Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1073858403259187
Keywords
neuroprotection; preconditioning; therapeutic window
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In the 10 years since neurotrophic activity was first reported for erythropoietin (EPO), a broad understanding of its multiple paracrine/autocrine functions has emerged. Recent studies firmly establish EPO as a multifunctional molecule, typical of the pliotrophic cytokine superfamily of which it is a member. The realization that EPO activates neuroprotection by multiple mechanisms has identified a generalized system of local tissue protection with EPO as a critical component. Here, the authors characterize the biology of the local tissue-protective system, review data that support this concept, and suggest why nonhematopoietic analogues of EPO may be better choices as therapeutics.
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