Journal
BEHAVIORAL NEUROSCIENCE
Volume 118, Issue 2, Pages 443-448Publisher
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.118.2.443
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- NIMH NIH HHS [MH50479] Funding Source: Medline
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Uncontrollable or inescapable shock (IS) produces behavioral changes that are characterized by a sensitized fear system and a deficit in fight-flight responding. These behavioral changes have been argued to represent an anxiety-like state produced by the uncontrollability of the stressor. The bed nucleus of the stria terminalis (BNST) has been implicated in the mediation of long-duration responses to unpredictable stressors, which have also been argued to represent anxiety. In the present study, the effects of BNST chemical lesion on the IS-induced sensitization of freezing to an environment previously paired with shock and the IS-induced impairment of escape responding were investigated. BNST chemical lesion blocked the potentiation of freezing and the increases in escape latency that normally follow IS.
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