Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 16, Issue 2, Pages 140-145Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2004.01.005
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- NIDDK NIH HHS [R01 DK061397, DK61397, DK34134] Funding Source: Medline
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Across the animal kingdom the apical junction complex of epithelial cells creates both a permeability barrier and cell polarity. Although based on overlapping and evolutionarily conserved proteins, the cell-cell contacts of nematodes, flies and mammals appear to differ in morphology and functional organization. Emerging evidence shows that the selective pore-like properties of vertebrate and invertebrate barriers are created by the claudin family. Similarly, assembly of the barriers requires a conserved set of polarity-generating protein complexes, particularly the PAR protein complexes.
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